High grade table
| Name of lymphoma | Other features |
|---|---|
| Diffuse large cell lymphoma – commonest type | People of working age likely to recover with treatment and become long term survivors (>60% survival at 8 years) |
| Mediastinal large B-cell lymphoma | Often affects women aged 30-40. variable prognosis |
| Follicular large cell lymphoma | No special features |
| Anaplastic large cell lymphoma | Disease often affects the skin - causing skin lesions. People of working age likely to recover with treatment and become long term survivors |
| Extranodal NK/T-cell lymphoma | Often presents as a tumour in the nose and commonly affects the brain. Has a much worse survival rate than other high grade lymphomas. |
| Lymphomatoid granulomatosis | Often presents as a tumour in the nose or lung. |
| Angioimmunoblastic T-cell lymphoma | Likely to have severe swelling of lymph node groups and severe ‘B’ symptoms. May be treated with chemotherapy or steroid drugs alone. Poor outcome. Median overall survival 15 months. |
| Peripheral T-cell lymphoma | Poor survival despite treatment –likely to have needs. |
| Enteropathy type intestinal T-cell lymphoma | A type of lymphoma associated with untreated celiac disease. Surgery to remove affected bowel is often part of diagnosis or treatment – in addition to chemotherapy. More aggressive than commonest type– likely to have needs. |
| Intravascular large B-cell lymphoma (intravascular lymphomatosis) | More aggressive than commonest type– likely to have needs. |
| Burkitt's lymphoma/diffuse noncleaved –cell lymphoma | Aggressive treatment is required including intrathecal chemotherapy and prophylactic cranial irradiation to prevent brain spinal cord involvement. |
| Lymphoblastic lymphoma | Very aggressive form of NHL – more common in younger people. Bone marrow transplant is treatment of choice. |
| Adult T-cell leukaemia/lymphoma | Lymphoma associated with Human T-cell lymphotropic virus type 1. May be treated with zidovudine and interferon. Outcome very poor. |
| Mantle cell lymphoma | Median survival with this disease is 3-5 years. It affects older people more often than people of working age. (This was classified as low grade in the past) |
| post-transplant lymphoproliterative disorder | Type of lymphoma that occurs in people taking immunosuppressant drugs – usually after organ transplant. May resolve if drugs can be stopped but this may not be feasible if transplanted organ is vital to survival e.g. heart? Poor prognosis |
| True histiocytic lymphoma | Very rare. |
| Primary effusion lymphoma | Type of lymphoma affecting people with HIV. Prognosis is poor – likely to have needs. |
Amended February 2009
