Causes of Cirrhosiss

The commonest causes of cirrhosis in the UK are:

• Alcohol misuse - 60 - 80%,
• Viral hepatitis - 10 - 20%,
• Biliary cirrhosis - 5 - 10%,
• Haemochromatosis - 5%.

There are many other much less common diseases that result in cirrhosis including:

• Metabolic diseases - Wilson's disease, alpha-1 anti-trypsin deficiency, galactosaemia, congenital tyrosinosis,
• Autoimmune chronic active hepatitis,
• Hepatic venous outflow obstruction:

• Veno occlusive disease,
• Budd Chiari syndrome,
• "Cardiac cirrhosis" from constrictive pericarditis.

• Toxins/ drugs e.g. methrotrexate, amiodarone, bush tea,
• Cryptogenic - cirrhosis of unknown origin.